The rain has fallen almost constantly for more than a day, flooding neighborhoods in low-lying areas of the state.
Officials were responding quickly because the waters were rising fast - even as Isaac meandered slowly northward Thursday on a path toward Arkansas.
President Barack Obama declared federal emergencies in Louisiana and Mississippi. The declarations free up federal aid for affected areas.
A tow truck driver was killed Thursday morning in Picayune, Miss., when a tree fell on his truck, crushing the cab.
Utility companies say they are working to restore power to more than 63,000 customers in south and central Mississippi.
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