Thousands of runner showed up for the run, some with gloves and layer upon layers of clothing.
The theme this year for the Run with Donna was 'Finish Breast Cancer'. The 26.2 with Donna Mission is to passionately produce world class events to raise funds for ground breaking breast cancer research and empower women living with breast cancer.
When each runner was finished, volunteers offered the runners water and a blanket or cover to help keep them warm after a chilly run.
On one of the coldest mornings of the year, it wasn't only freezing for the runners, but also for the volunteers who dedicated their time and energy. Most volunteers were scheduled to man their stations from 7 a.m. through 3 p.m Sunday.
Physical therapist Olivia Davis with the Mayo Clinic said the runners were cramping up more than usual, their bodies not accustomed to this cold. There was as station at the event to help runners with cramps and soreness after the run.
Medals were also given to the runners for their support in fighting breast cancer.
"The race is the coldest of the year," volunteer Tom Bucher said. "They don't plan it like that, but people are still volunteering, having a good time.'
Hundreds of friends and family members lined the streets to support the runners.
Volunteers and participants say Donna Deegan's national marathon to fight breast cancer always seems to usher in arctic air. They say no matter the weather, they will still continue to support the event and the fight against breast cancer.